New papers offer insights into process of malarial drug resistance

Author: William G. Gilroy


Malaria, one of the oldest diseases known to man, has shown no signs of slowing down as it ages. More than 1 million children die from malaria in sub-Saharan Africa each year, and in areas along the Thailand/Cambodian border multiple drug-resistant strains of the disease are becoming commonplace.

With the previously mainstay antimalarial drug chloroquine nearly ineffective due to drug resistance and traditional public health approaches such as mosquito netting offering uneven results, two new papers by University of Notre Dame biologist Michael Ferdig suggest that the means of combating this old foe may lie in the new tools of genomics and bioinformatics.

In the papers, Ferdig points out that development of the malaria parasite Plasmodium falciparum in the blood is driven by a number of different genes expressed at different times and at different levels. Exactly what influences such transcriptional changes remains elusive, particularly in regard to important phenotypes like drug resistance.

Ferdig and his collaborators combined classical genetics with cutting-edge genomic methods to illuminate previously unrecognized transcriptional complexity and variation in Plasmodium falciparum and possibly master regulators within large copy number variants that contribute to the drug-resistant phenomena in malaria parasites.

By uncovering the genetic"architecture"of numerous drug responses and identifying key regulators that control these responses, Ferdig hopes to map new approaches to conquering drug resistant malarial genes.

One paper from the Ferdig lab appeared in the journal PLoS Biology. The second, in collaboration with Tim Anderson at Southwest Biomedical Research Foundation, appeared in PLoS Genetics.

Feridg’s research is conducted in Notre Dame’s Eck Institute for Global Health, a world-renowned collaborative research program named in honor of the family of the late alumnus Frank E. Eck.

Research in the institute is focused on human pathogens and their invertebrae and vertebrae vectors, the diseases caused by these organisms and the impact of these diseases on human society. Members of the institute are concerned in particular with the impact of infectious diseases in less developed parts of the world. In addition to malaria, diseases studied at the institute include toxoplasmosis, tuberculosis, lymphatic filariasis, leishmaniasis, dengue, and West Nile encephalitis.

_ Contact: Michael Ferdig, assistant professor, biological sciences, 574-631-9973,_ " "


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