Kasturi Haldar

Kasturi Haldar

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Julius Nieuwland Professor of Biological Sciences
Parsons-Quinn Director, Center for Rare and Neglected Diseases

Office: 107A Galvin Life Science Center
Phone: 574-631-1474
Email: khaldar@nd.edu

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Areas of Expertise

Understanding disease pathology and developing treatments in rare and neglected diseases

The first Parsons-Quinn Director of Notre Dame’s Center for Rare and Neglected Diseases, Haldar focuses on understanding cell function and cerebral disease in muring models that are important areas for discovering disease treatments. Her identification of how the malaria parasite attacks red blood cells revealed that a common blood pressure drug can be used to treat the disease, preventing the parasite from invading the cell. More recently, she researched the role of lipids, which has led to understanding how statins — the drugs used to lower cholesterol levels — protect against bacterial infection. Haldar’s work also has revealed new pathways that control the proper function of cellular components called lysosomes, which are defective in storage and neurodegenerative diseases such as Niemann-Pick Type C (NPC). Current studies focus on development of a quantitative, rapid neurobehavioral score by which to measure NPC disease in mice. Using this scale she is able to identify unique genetic signatures associated with disease progression, develop biomarkers as well as screen for drugs to treat disease in mice, in order that drugs can be progressed to clinical trials and therapeutic utilization.

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Fighting for the Lives of Children

ND NEWSWIRE ARTICLES

New formulation of FDA-approved drug may help treat Niemann-Pick Type C disease
Researchers identify molecular mechanism responsible for making malaria parasites drug-resistant
Notre Dame researchers report fundamental malaria discovery
Undergraduate students publish their clinical research in major scientific journal
Ten Notre Dame faculty members named AAAS fellows
$5 million gift from James Parsons and Carrie Quinn to endow directorship at Notre Dame
Rare and neglected diseases are focus of new center
Notre Dame researchers receive $100,000 Grand Challenges Exploration grants for innovative global health research