Jeffrey Schorey

Jeffrey Schorey

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George B. Craig Jr. Professor of Biological Sciences

Office: 129 Galvin Life Sciences
Phone: 574-631-3734 (office)
574-631-9697 (lab)

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Areas of Expertise

  • Cellular & Moleculular Biology
  • Microbiology & Immunology
  • Infectious & Vector-Borne Diseases
  • Mycobacterial pathogenesis
  • Infectious Diseases
  • Immunity
  • Mouse models
  • TB diagnostics, drug development & vaccine development

Schorey’s research focuses on the interaction between mycobacteria and the macrophage—the major cell in the body infected by mycobacteria. Activated macrophages, which function as an important component of the innate immune system, also play a vital role in the control of a mycobacterial infection. Ongoing studies aim at characterizing the macrophage signaling pathways activated upon infection by pathogenic and non-pathogenic mycobacteria species/strains and in order to better understand the virulence mechanisms used by pathogenic mycobacteria. Another major line of Schorey’s investigation is deciphering the role of secreted exosomes in disease transmission. Using cell and animal models, he showed that some mycobacterial components can be released from infected cells via small membrane vesicles called exosomes, and that the released exosomes modulate the host’s innate and acquired immune response. In a related project, supported by the Bill and Melinda Gates Foundation, he is also are investigating whether exosomes, which are present in human TB patient serum, can be used as diagnostic markers of disease or as potential TB vaccines.


Fighting To Stop Tuberculosis

Jeffrey Schorey, Ph.D., on exosomes


Ten Notre Dame faculty members named AAAS fellows
Team of scientists wins grant to research tuberculosis diagnostics
Notre Dame researchers receive $100,000 Grand Challenges Exploration grants for innovative global health research
Notre Dame to commit $80 million to new research initiatives
Strategic Academic Planning Committee selects research proposals