Francis Castellino

Francis Castellino

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Director, WM Keck Center for Transgene Research,
Kleiderer-Pezold Professor of Biochemistry

Office: 230 Raclin-Carmichael Hall
Phone: 574-631-8996

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Areas of Expertise

Blood clots, hemostasis and inflammation

Director of Notre Dame’s W.M. Keck Center for Transgene Research, Castellino studies the mechanism by which the human body forms and dissolves blood clots. Among a number of important finds, he has established the mechanism of plasminogen activation, a key function of the body’s formation of the enzyme that dissolves clots. His research also focuses on cell-specific glycosylation of proteins and brain NMDA receptor agonists and antagonists. Major tools of his laboratory include cloning, mutagenesis and expression of variant recombinant proteins and individual protein domains, immunochemical studies of the proteins, as well as physical and chemical analysis of their solution structures. Along with its scientific importance, his research bears directly on the treatment of heart disease, strokes and hemophilia.


Notre Dame Research: Keck Center for Transgene Research.

Cancer research.


Notre Dame hosts international biology workshop at Rome Global Gateway
New technology helps ER doctors make critical decisions
Castellino to receive 2008 WYETH-ISFP Prize
Keck Center: Battling diseases to save lives
$9 million NIH grant heightens Keck research profile