David Hyde

David Hyde

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Rev. Howard J. Kenna, C.S.C., Memorial Director of the Center for Zebrafish Research

Office: 027 Galvin Life Sciences Center
Phone: 574-631-8054
Email: dhyde@nd.edu

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Areas of Expertise

Retinal/neuronal regeneration, adult/somatic stem cells, regenerative biology, retinal development, genetic reprogramming, cell signaling pathways

Hyde studies a variety of processes associated with the zebrafish eye, including development of the retina and lens, retinal cell death (neuronal degeneration) and the role of adult stem cells in regeneration of retinal neurons. The zebrafish retina is an excellent model because it serves as an easily accessible portion of the central nervous system. This work has direct relevance for understanding the mechanisms of neuronal cell death in a variety of human retinal diseases, such as macular degeneration, retinitis pigmentosa, diabetic retinopathy and glaucoma, and the development of novel stem cell therapies. Under Hyde’s direction, the Center for Zebrafish Research is developing state-of-the-art approaches to study and use zebrafish in medical research. This includes genetic, molecular, electrophysiological and behavioral approaches. The center is one of the largest zebrafish facilities in the Midwest and houses a large collection of mutant and transgenic zebrafish. Hyde also serves as a member of the National Institutes of Health (NIH) Center for Scientific Review Biology and Diseases of the Posterior Eye Study Section.


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