Crislyn D'Souza-Schorey

Crislyn D'Souza-Schorey

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Morris Pollard Professor of Biological Sciences
Department Chair

Office: 100 Galvin Life Science Center
Phone: 574-631-5257

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Areas of Expertise

Cancer, cancer cell invasion, cell migration, metastasis, cancer biomarkers

A major line of investigation in D’Souza-Schorey’s research laboratory is to understand the cellular basis of tumor metastases. The acquisition of the invasive phenotype — when cells acquire the ability to break away from the primary tumor and invade the surrounding tissue — has been the focal point of the laboratory’s research. Known for her work on the ARF6 protein, which is deregulated in cancers, her laboratory continues to study early changes in tumor cells that facilitate disease progression. A highly visible scientist, D’Souza-Schorey’s work has been published in leading scientific journals and supported by several funding agencies including the American Cancer Society, the Department of Defense, the Leukemia and Lymphoma Society of America and the National Cancer Institute of the National Institutes of Health. Often called upon to speak at national and international meetings, she has been recognized with a host of awards and honors throughout her career, including the Michael K. Guest Award for Innovative Cancer Research from the Walther Cancer Institute. She has served as a standing member of the NIH Intercellular Interactions study section and continues to serve on grant review panels of several national and international funding agencies. She was elected Fellow of the American Association for the Advancement of Science (AAAS) in 2012.


Cancer Research at Notre Dame


New paper sheds light on harnessing the clinical potential of microvesicles released from cancer cells
Notre Dame researchers offer new insights on cancer cell signaling
Ten Notre Dame faculty members named AAAS fellows
Notre Dame researcher’s paper examines the biology and clinical application of tumor-derived microvesicles
Edward Larkin named 2011 valedictorian
Notre Dame researchers receive medical technologies grants for Indiana-based initiatives
New Notre Dame study provides insights into the molecular basis of tumor cell behavior
New study provides insights into the behavior of tumor cells
Tackling cancer’s mysteries
Walther researchers provide insight into cell migratory behavior
Notre Dame biologist makes important Huntington’s discovery


ScienceNews — Cells in groups may promote cancer’s spread
Science News for Students — Cell gangs may help cancer spread
Science Daily — New insights on cancer cell signaling
WNDU — Notre Dame researchers making cancer breakthroughs
Science Daily — Insights Into The Molecular Basis Of Tumor Cell Behavior
Biotechniques — Profile of Crislyn D’Souza-Schorey