The University of Notre Dame will host the XIV International Workshop on Molecular and Cellular Biology of Plasminogen Activation from June 4 through June 8 (Tuesday through Saturday).
The co-chairs of the conference are Francis J. Castellino and Victoria A. Ploplis of Notre Dame’s W. M. Keck Center for Transgene Research. The conference is co-sponsored by the Indiana University School of Medicine-South Bend and Memorial Hospital of South Bend.
The plasminogen activation system and related proteolytic systems are essential regulators of tissue remodeling events as well as of cell functions through activation of cell signaling pathways. Through early studies involving in vitro biochemical investigations and, more recently, in vivo biological studies involving gene modified technology, the plasminogen activation pathway has been identified as a major participant in the regulation and progression of a number of clinically relevant human diseases. These include cancer, cardiovascular diseases, neurological pathologies and bacterial pathogenesis.